TElomeres and human disease

Impaired function of telomeres - the caps that protect chromosome ends - occurs with normal aging and in settings of disease. Telomere dysfunction impairs tissue regeneration and  blocks cancer development. We seek to understand how this process influences degenerative disease and cancer.

 

 
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Tissue homeostasis and regeneration

Maintenance of many tissues fails with advanced aging and disease. We study the underlying mechanisms governing tissue homeostasis and repair. 

 

 
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Origins of cancer

The cellular origins of cancer remain largely mysterious. We study the early stages of human carcinogenesis and how cancers acquire cellular immortality.

 

 
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Telomerase function in cancers and stem cells

The telomerase enzyme lengthens telomeres, a critical step in cellular immortality. We seek to understand how telomerase functions inside living human cells.