FEATURED PUBLICATIONS FROM THE ARTANDI LAB

PUBLICATIONS

  1. Pech MF, Garbuzov A, Hasegawa K, Sukhwani M, Zhang RJ, Benayoun BA, Brockman SA, Lin S, Brunet A, Orwig KE, Artandi SE. High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells. 2015. Genes and Development, 29(23):2420-34. PMID: 26584619
  2. Roake CM, Artandi SE. 2015. Keeping It in the Family: ATRX Loss Promotes Persistent Sister Telomere Cohesion in ALT Cancer Cells. Cancer Cell, 14:277-9. PMID: 26373274
  3. Raval A, Behbehani GK, Nguyen le XT, Thomas D, Kusler B, Garbuzov A, Ramunas J, Holbrook C, Park CY, Blau H, Nolan GP, Artandi SE, Mitchell BS. 2015. Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice. PMID:26133370.
  4. Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y. 2015. Stem Cells and Aging: What's Next? Cell Stem Cell, 16: 578-81. PMID:26247067.
  5. Harel I, Benayoun BA, Machado B, Singh BP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE and Brunet A. 2015. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell, 160:1013-26. PMID: 25684364
  6. Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, Wernig M. 2015. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell. 16:39-50. PMID: 25467916
  7. Freund A, Zhong F, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE. 2014. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Cell, 159:1389-403. PMID: 25467444
  8. Batista L and Artandi SE. 2013. Understanding telomere diseases through analysis of disease-specific iPS cells. Current Opinions Gen. Dev., 23:526-33. PMID: 23993228
  9. Diala I, Wagner N, Magdinier F, Shkreli M, Sirakov M, Bauwens S, Schluth-Bolard C, Simonet T, Renault VM, Ye J, Djerbi A, Pineau P, Choi J, Artandi S, Dejean A, Plateroti M, Gilson E. 2013. Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway. EMBO Reports. 14(4):356-63. doi: 10.1038/embor.2013.16. Epub 2013 Feb 22. PMID: 23429341
  10. Zhong F, Batista LZ, Freund A, Pech MF, Venteicher AS, Artandi SE (2012) TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell. 150:481-94. PMID: 22863003
  11. Shkreli, M., Sarin, K.Y., Pech, M.F., Papeta, N., Chang, W., Brockman, S.A., Cheung, P., Lee, E., Kuhnert, F., Olson, J.L., Kuo, C.J., Gharavi, A.G., D'Agati, V.D., and S.E. Artandi. 2011. Reversible cell cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nature Medicine. 18: 481-94. PMID: 22138751
  12. Chu, C., Qu, K., Zhong, F., Artandi, S.E., and H.W. Chang. 2011. Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions. Mol. Cell. 44:667-678. PMID: 21963238
  13. Sebastiano, V., Maeder, M.L., Angstman, J.F., Haddad, B., Khayter, C., Yeo, D.T., Goodwin, M.J., Hawkins, J.S., Ramirez, C.L., Batista, L.F., Artandi, S.E., Wernig, M., and J.K. Joung. 2011. In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells. (11):1717-26. PMID: 21898685
  14. Batista, L.F.Z., Pech, M.F., Zhong, F.Z., Nguyen, H.N., Xie, K.T.,  Zaug, A.J., Crary, S.M., Choi, J., Sebastiano, V., Cherry, A., Giri, N., Wernig, M., Alter, B.P., Cech, T.R., Savage, S.A, Reijo Pera, R.A, and S.E. Artandi. 2011. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature. 474:399-402. PMID: 21602826
  15. Pech, M. F. and S.E. Artandi. 2011. TRAPping telomerase within the intestinal stem cell niche. EMBO J. 30:986-7. PMID: 21407250
  16. Zhong, F., Savage, S.A, Shkreli, M., Giri, N., Jessop, L., Myers, T., Chen, R., Alter, B.A., and S.E. Artandi. 2011. Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. Genes and Development. 25:11-16. PMID: 21205863
  17. Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD. 2010. Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. J. Cell Science. 123:4351-65. PMID: 21098636
  18. Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz. J.H., Artandi, S.E., and H.M. Blau. 2010. Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice. Cell. 143:1059-1071. PMID: 21145579
  19. Artandi, S.E. and R.A. DePinho. 2010. Telomeres and telomerase in cancer. Carcinogenesis. 31:9-18. PMID: 19887512
  20. Artandi, S.E. and J.P. Cooper. 2009. Reverse transcribing the code for chromosome stability. Mol. Cell. 36:715-719. PMID: 20005831
  21. Choi, J. and S.E. Artandi. 2009. Stem cell aging and aberrant differentiation within the niche. Cell Stem Cell. 5:6-8. PMID: 19570507
  22. Park, J.-I., Venteicher, A.S., Hong, J.Y., Choi, J., Jun, S., Shkreli, M., Chang, W., Meng, Z., Cheung, P., Ji, H., McLaughlin, M., Veenstra, T.D., Nusse, R., McCrea, P.D., and S. E. Artandi. 2009. Telomerase modulates Wnt signaling by association with target gene chromatin. Nature, 460:66-72. PMID: 19571879
  23. Batista, L.F. and S.E. Artandi. Telomere uncapping, chromosomes and carcinomas. 2009. Cancer Cell. 15:455-457. PMID: 19477422
  24. Venteicher, A.S. and S. E. Artandi. 2009. TCAB1: Driving telomerase to Cajal bodies. Cell Cycle. 8:1329-31. PMID: 19342896
  25. Venteicher, A.S., Abreu, E.B., Meng, Z., McCann, K.E., Terns, R.M., Veenstra, T.D., Terns, M.P., and S. E. Artandi. 2009. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science. 323:644-648. PMID: 19179534
  26. Gao, Q., Reynolds, G.E., Miller, D., Cheung, P. Artandi, S. E. and J. P. Murnane.  2008. Telomerase-dependent and independent chromosome healing in mouse embryonic stem cells.  DNA Repair (Amst.), 7:1222-1249. PMID: 18502190
  27. Venteicher, A.S., Meng, Z., Mason, P. J., Veenstra, T.D., and S. E. Artandi. 2008. Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell. 132:945-57. PMID: 18358808
  28. Choi, J., Southworth, L., Sarin, K., Venteicher, A. S., Ma, W., Chang, W., Cheung, P., Jun, S., Artandi, M.K., Shah, N., Kim, S.K. and S. E. Artandi. 2008.  TERT promotes epidermal proliferation through transcriptional control of a Myc- and Wnt-related developmental program.  PLoS Gen. 4(1):e10. PMID: 18208333
  29. Rajaraman, S., Choi, J., Cheung, P., Beaudry, V., Moore, H. and S. E. Artandi. 2007. Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo.  Proc. Natl. Acad. Sci. 104:17747-52. PMID: 17965232
  30. Sarin, K. and S. E. Artandi. 2007.  Aging, graying and loss of melanocyte stem cells. Stem Cell Rev. 3: 212-217. PMID: 17917134
  31. Maser, R.S., Wong, K.K., Sahin, E., Xia, H., Naylor, M., Hedberg, H.M., Artandi, S.E., and R.A. DePinho. 2007. DNA-PKcs is not required for dysfunctional telomere fusion and checkpoint response in the telomerase deficient mouse. Mol. Cell. Biol. 27:2253-65. PMID: 17145779
  32. Artandi, S.E. 2006. Telomeres, telomerase and human disease. New Engl. J. Med. 355:1195-1197. PMID: 16990382
  33. Artandi, S.E. 2006.  Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene.  J. Exp. Med. 203:1143-45. PMID: 16682501
  34. Middleman, E., Choi, J., Venteicher, A. S., Cheung, P., and S.E. Artandi. 2006.  Regulation of cellular immortalization and steady-state protein levels of the telomerase reverse transcriptase through its carboxy-terminal domain.  Mol. Cell. Biol. 26:2146-2159. PMID: 16507993
  35. Sarin, K. Y., Cheung, P., Lee, E., Gilison, D., Artandi, M.K., Oro, A., and S. E. Artandi. 2005. Conditional telomerase induction causes proliferation of hair follicle stem cells.  Nature. 436:1048-1052. PMID: 16107853
  36. Artandi, S.E. and Attardi, L.D. 2005. Pathways connecting telomeres and p53 in senescence, apoptosis and cancer. Biochem. Biophys. Res. Commun. 331:881-90. PMID: 15865944
  37. Artandi, S.E., 2002.  Complex roles for telomeres and telomerase in breast carcinogenesis.  Breast Cancer Research 5:37-41. PMID: 12559044
  38. O'Hagan, R., Chang, S., Maser, R., Mohan, R., Artandi, S.E., Chin, L. and R.A. DePinho. 2002.  Telomere dysfunction provokes regional amplification and deletion in cancer genomes.  Cancer Cell 2:149-153. PMID: 12204535
  39. Artandi, S.E., 2002.  Telomere shortening and cell fates in mouse models of neoplasia.  Trends Mol. Med., 8:44. PMID: 11796266
  40. Artandi, S. E., Alson, S., Tietze, M., Sharpless, N., Ye, S., Greenberg, R., Castrillon, D., Horner, J., Weiler, S., Carrasco, R. and R. DePinho. 2002. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl. Acad. Sciences, 99:8191-8196. PMID: 12034875
  41. Artandi, S.E., and DePinho R.A., 2000. A critical role for telomeres in suppressing and facilitating carcinogenesis. Current Opinions in Genetics and Development, 10:39-46. PMID: 10679392
  42. Artandi, S.E., and DePinho R.A., 2000.  Mice without telomerase: what can they teach us about human cancer?  Nature Medicine 6:852-855. PMID: 10932211
  43. Wong, K.-K., Chang S., Weiler, S.R., Ganesan S., Chaudhura J., Zhu C., Artandi S.E., Rudolph K.L., Gottlieb G.J., Chin L., Alt F.W., and DePinho, R.A., 2000.  Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.  Nature Genetics.  26:85-88. PMID: 10973255
  44. Artandi, S.E., Chang, S., Lee, S.-L., Alson S., Gottlieb, G.J., Chin, L., and DePinho, R.A., 2000.  Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.  Nature 406:641-644. PMID: 10949306
  45. Chin, L., Artandi, S.E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., and DePinho, R. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97: 527. PMID: 10338216