FEATURED PUBLICATIONS FROM THE ARTANDI LAB

PUBLICATIONS

  1. Roake CM, Chen L, Chakravarthy AL, Ferrell JE Jr, Raffa GD, Artandi SE. 2019.Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. Mol. Cell. Mar 28. pii: S1097-2765(19)30144-3. doi: 10.1016/j.molcel.2019.02.033. [Epub ahead of print] PMID: 30930056. Click for link to paper.

  2. Chen L, Roake CM, Freund A, Batista PJ, Tian S, Yin YA, Gajera CR, Lin S, Lee B, Pech MF, Venteicher AS, Das R, Chang HY, and Artandi SE. 2018. An activity switch in human telomerase based on RNA conformation and shaped by TCAB1. Cell, 174:218-230. PMID: 29804836.

  3. Lin S, Nascimento EM, Gajera C, Chen L, Neuhoefer P, Garbuzov A, Wang S, and Artandi SE. 2018. Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Nature, 556:244-248. PMID:29618815.       Click for link to paper.  

  4. Garbuzov A, Pech MF, Hasegawa K, Sukhwani M, Zhang RJ, Orwig KE, Artandi SE. 2018. Purification of GFRα1+ and GFRα1- Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination. Stem Cell Reports. 10(2):553-567. PMID:29337115

  5. Pech MF, Garbuzov A, Hasegawa K, Sukhwani M, Zhang RJ, Benayoun BA, Brockman SA, Lin S, Brunet A, Orwig KE, Artandi SE. 2015. High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells. . Genes and Development, 29(23):2420-34. PMID: 26584619

  6. Roake CM, Artandi SE. Keeping It in the Family: ATRX Loss Promotes Persistent Sister Telomere Cohesion in ALT Cancer Cells. Cancer Cell, 14:277-9. PMID: 26373274

  7. Raval A, Behbehani GK, Nguyen le XT, Thomas D, Kusler B, Garbuzov A, Ramunas J, Holbrook C, Park CY, Blau H, Nolan GP, Artandi SE, Mitchell BS. 2015. Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice. PLoS One, 10:e0131722. PMID:26133370.

  8. Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y. 2015. Stem Cells and Aging: What's Next? Cell Stem Cell, 16: 578-81. PMID:26247067.

  9. Harel I, Benayoun BA, Machado B, Singh BP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE and Brunet A. 2015. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell, 160:1013-26. PMID: 25684364

  10. Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, Wernig M. 2015. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell. 16:39-50. PMID: 25467916

  11. Freund A, Zhong F, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE. 2014. Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Cell, 159:1389-403. PMID: 25467444

  12. Batista L and Artandi SE. 2013. Understanding telomere diseases through analysis of disease-specific iPS cells. Current Opinions Gen. Dev., 23:526-33. PMID: 23993228

  13. Diala I, Wagner N, Magdinier F, Shkreli M, Sirakov M, Bauwens S, Schluth-Bolard C, Simonet T, Renault VM, Ye J, Djerbi A, Pineau P, Choi J, Artandi S, Dejean A, Plateroti M, Gilson E. 2013. Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway. EMBO Reports. 14(4):356-63. doi: 10.1038/embor.2013.16. Epub 2013 Feb 22. PMID: 23429341

  14. Zhong F, Batista LZ, Freund A, Pech MF, Venteicher AS, Artandi SE (2012) TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell. 150:481-94. PMID: 22863003

  15. Shkreli, M., Sarin, K.Y., Pech, M.F., Papeta, N., Chang, W., Brockman, S.A., Cheung, P., Lee, E., Kuhnert, F., Olson, J.L., Kuo, C.J., Gharavi, A.G., D'Agati, V.D., and S.E. Artandi. 2011. Reversible cell cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nature Medicine. 18: 481-94. PMID: 22138751

  16. Chu, C., Qu, K., Zhong, F., Artandi, S.E., and H.W. Chang. 2011. Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions. Mol. Cell. 44:667-678. PMID: 21963238

  17. Sebastiano, V., Maeder, M.L., Angstman, J.F., Haddad, B., Khayter, C., Yeo, D.T., Goodwin, M.J., Hawkins, J.S., Ramirez, C.L., Batista, L.F., Artandi, S.E., Wernig, M., and J.K. Joung. 2011. In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells. (11):1717-26. PMID: 21898685

  18. Batista, L.F.Z., Pech, M.F., Zhong, F.Z., Nguyen, H.N., Xie, K.T., Zaug, A.J., Crary, S.M., Choi, J., Sebastiano, V., Cherry, A., Giri, N., Wernig, M., Alter, B.P., Cech, T.R., Savage, S.A, Reijo Pera, R.A, and S.E. Artandi. 2011. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature. 474:399-402. PMID: 21602826

  19. Pech, M. F. and S.E. Artandi. 2011. TRAPping telomerase within the intestinal stem cell niche. EMBO J. 30:986-7. PMID: 21407250

  20. Zhong, F., Savage, S.A, Shkreli, M., Giri, N., Jessop, L., Myers, T., Chen, R., Alter, B.A., and S.E. Artandi. 2011. Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. Genes and Development. 25:11-16. PMID: 21205863

  21. Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD. 2010. Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. J. Cell Science. 123:4351-65. PMID: 21098636

  22. Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz. J.H., Artandi, S.E., and H.M. Blau. 2010. Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice. Cell. 143:1059-1071. PMID: 21145579

  23. Artandi, S.E. and R.A. DePinho. 2010. Telomeres and telomerase in cancer. Carcinogenesis. 31:9-18. PMID: 19887512

  24. Artandi, S.E. and J.P. Cooper. 2009. Reverse transcribing the code for chromosome stability. Mol. Cell. 36:715-719. PMID: 20005831

  25. Choi, J. and S.E. Artandi. 2009. Stem cell aging and aberrant differentiation within the niche. Cell Stem Cell. 5:6-8. PMID: 19570507

  26. Park, J.-I., Venteicher, A.S., Hong, J.Y., Choi, J., Jun, S., Shkreli, M., Chang, W., Meng, Z., Cheung, P., Ji, H., McLaughlin, M., Veenstra, T.D., Nusse, R., McCrea, P.D., and S. E. Artandi. 2009. Telomerase modulates Wnt signaling by association with target gene chromatin. Nature, 460:66-72. PMID: 19571879

  27. Batista, L.F. and S.E. Artandi. Telomere uncapping, chromosomes and carcinomas. 2009. Cancer Cell. 15:455-457. PMID: 19477422

  28. Venteicher, A.S. and S. E. Artandi. 2009. TCAB1: Driving telomerase to Cajal bodies. Cell Cycle. 8:1329-31. PMID: 19342896

  29. Venteicher, A.S., Abreu, E.B., Meng, Z., McCann, K.E., Terns, R.M., Veenstra, T.D., Terns, M.P., and S. E. Artandi. 2009. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science. 323:644-648. PMID: 19179534

  30. Gao, Q., Reynolds, G.E., Miller, D., Cheung, P. Artandi, S. E. and J. P. Murnane. 2008. Telomerase-dependent and independent chromosome healing in mouse embryonic stem cells. DNA Repair (Amst.), 7:1222-1249. PMID: 18502190

  31. Venteicher, A.S., Meng, Z., Mason, P. J., Veenstra, T.D., and S. E. Artandi. 2008. Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell. 132:945-57. PMID: 18358808

  32. Choi, J., Southworth, L., Sarin, K., Venteicher, A. S., Ma, W., Chang, W., Cheung, P., Jun, S., Artandi, M.K., Shah, N., Kim, S.K. and S. E. Artandi. 2008. TERT promotes epidermal proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Gen. 4(1):e10. PMID: 18208333

  33. Rajaraman, S., Choi, J., Cheung, P., Beaudry, V., Moore, H. and S. E. Artandi. 2007. Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo. Proc. Natl. Acad. Sci. 104:17747-52. PMID: 17965232

  34. Sarin, K. and S. E. Artandi. 2007. Aging, graying and loss of melanocyte stem cells. Stem Cell Rev. 3: 212-217. PMID: 17917134

  35. Maser, R.S., Wong, K.K., Sahin, E., Xia, H., Naylor, M., Hedberg, H.M., Artandi, S.E., and R.A. DePinho. 2007. DNA-PKcs is not required for dysfunctional telomere fusion and checkpoint response in the telomerase deficient mouse. Mol. Cell. Biol. 27:2253-65. PMID: 17145779

  36. Artandi, S.E. 2006. Telomeres, telomerase and human disease. New Engl. J. Med. 355:1195-1197. PMID: 16990382

  37. Artandi, S.E. 2006. Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene. J. Exp. Med. 203:1143-45. PMID: 16682501

  38. Middleman, E., Choi, J., Venteicher, A. S., Cheung, P., and S.E. Artandi. 2006. Regulation of cellular immortalization and steady-state protein levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Mol. Cell. Biol. 26:2146-2159. PMID: 16507993

  39. Sarin, K. Y., Cheung, P., Lee, E., Gilison, D., Artandi, M.K., Oro, A., and S. E. Artandi. 2005. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature. 436:1048-1052. PMID: 16107853

  40. Artandi, S.E. and Attardi, L.D. 2005. Pathways connecting telomeres and p53 in senescence, apoptosis and cancer. Biochem. Biophys. Res. Commun. 331:881-90. PMID: 15865944

  41. Artandi, S.E., 2002. Complex roles for telomeres and telomerase in breast carcinogenesis. Breast Cancer Research 5:37-41. PMID: 12559044

  42. O'Hagan, R., Chang, S., Maser, R., Mohan, R., Artandi, S.E., Chin, L. and R.A. DePinho. 2002. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2:149-153. PMID: 12204535

  43. Artandi, S.E., 2002. Telomere shortening and cell fates in mouse models of neoplasia. Trends Mol. Med., 8:44. PMID: 11796266

  44. Artandi, S. E., Alson, S., Tietze, M., Sharpless, N., Ye, S., Greenberg, R., Castrillon, D., Horner, J., Weiler, S., Carrasco, R. and R. DePinho. 2002. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl. Acad. Sciences, 99:8191-8196. PMID: 12034875

  45. Artandi, S.E., and DePinho R.A., 2000. A critical role for telomeres in suppressing and facilitating carcinogenesis. Current Opinions in Genetics and Development, 10:39-46. PMID: 10679392

  46. Artandi, S.E., and DePinho R.A., 2000. Mice without telomerase: what can they teach us about human cancer? Nature Medicine 6:852-855. PMID: 10932211

  47. Wong, K.-K., Chang S., Weiler, S.R., Ganesan S., Chaudhura J., Zhu C., Artandi S.E., Rudolph K.L., Gottlieb G.J., Chin L., Alt F.W., and DePinho, R.A., 2000. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nature Genetics. 26:85-88. PMID: 10973255

  48. Artandi, S.E., Chang, S., Lee, S.-L., Alson S., Gottlieb, G.J., Chin, L., and DePinho, R.A., 2000. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406:641-644. PMID: 10949306

  49. Chin, L., Artandi, S.E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., and DePinho, R. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97: 527. PMID: 10338216